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Initial release | September 7, 2014 |
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Directors | Boo Ji-young |
Box office | 5. 2 million USD |
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ID | 2397299 |
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Immune discovery deals with all the cancer
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Immune discovery "deals with all the cancer"
The new technology could kill types of a variety of cancer cells, including breast and prostate-
A newly-discovered part of our immune system could be used for the treatment of cancer, say scientists.
The Cardiff University team found a method, with the killing of prostate, breast, lung and other cancers in laboratory tests.
not yet tested were to say patients, but the researchers That they had "enormous potential".
experts say That , although The Work is still in an early stage, it was very exciting.
What have you found?Our immune system is Our Body 's natural defense against infection, but it is also the cancer cells attacks.
The Scientists were in search of "unconventional" and previously undiscovered possibilities, the immune system naturally attacks tumors.
What they found was a T-cell in human blood. This is an immune system cell, the judge scan The Body , whether there is a threat That must be eliminated.
The difference is That you could attack, a variety of types of cancer.
"There is a chance you are dealing with here to any patients," researchers Prof Andrew Sewell told the BBC.
He added: "in the past, nobody believed That this could be possible.
"It is the prospect of a" one-size-fits-all " treatment of cancer, to destroy a single type of T-cells might be able to, many different types of cancer in the population increases. "
How does it work?the T-cells have "receptors" on The Surface , which allow them to "see" on a chemical level.
The Cardiff team discovered a T-cell and its receptor, the you could find and kill a variety of cancer cells in The Lab , including lungs, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells.
it is Crucial That it is to the left of normal tissues unaffected.
T-cells, the cancer cells attackExactly how it does this is still being researched.
This particular T-cell receptor interacts with a molecule called MR1, which on The Surface of each cell in the human body.
It is believed, MR1, identify the distorted metabolism in a cancer cell for the immune system.
"We are The First to describe a T-cell finds MR1 in cancer cells, which has not been done before, this is The First of its kind", a research fellow Garry Dolton told the BBC.
Why is this significant?the T-cell cancer therapies That already exist and the development of cancer immunotherapy is one of The Most exciting advances in The Field .
The best known example is the CAR-T - a life of drugs by genetic engineering of patient T-is to search for cells and to destroy cancer.
AUTO-T can have dramatic results, That the Transformation of some of the patients be terminally ill, in complete remission.
But the approach is very specific and works only diseases in a limited number of cancer, to detect where there is a clear goal, the training of T-cells.
And it has struggled to be a success in the "solid tumors" - the ones That the tumors form, instead of blood cancers such as leukemia.
The researchers say That their T-may cell lead receptor, to a "universal" cancer treatment.
how would it work in practice?The idea is That a blood sample would be taken from a cancer patient.
their T-cells would be extracted And Then genetically modified in a way That programmed it were, to the cancer-diagnosis-receptor.
The updated cells would be grown in huge quantities in the laboratory And Then put back into the patient. It is the same method is used to CAR-T therapies.
But, the research has only been tested on animals and on cells in the laboratory, and more security checks would be needed before the tests could begin.
What do The Experts say?Lucia Mori, Gennaro De Libero of the University of Basel in Switzerland, said the research had potential for "a large", but it was too early to tell, it would kinds of work in all of the cancer.
"We are very excited about the immunological features of this new T cell population, and the possible use of their TCRs in Tumor cell therapy", they said.
Daniel Davis , a professor of immunology at the University of Manchester, said: "at The moment this very basic research is not close to the actual medicines for patients.
"There is no question That it is a very exciting discovery, both for the promotion of our basic knowledge about the immune system and for the possibility of future new medicines. "
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cancer, cardiff university, breast cancer, prostate cancer, medical research
Source of news: bbc.com