DNA Polymerase Alpha

DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2. Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading errors.