Methotrexate photograph

Methotrexate

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Molar mass454. 44 g/mol
FormulaC20H22N8O5
MetabolismHepatic and intracellular
Elimination half-life3–10 hours (lower doses), 8–15 hours (higher doses)
ATC code WHO
ExcretionUrine (80–100%), faeces (small amounts)
Bioavailability60% at lower doses, less at higher doses.
Date of Reg.
Date of Upd.
ID2951745
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About Methotrexate


Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.

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