Paolo Macchiarini

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British teenager Shauna Davison received an experimental transplant in 2012, to extend in The Hope of your life. Her mother says she was told, in advance, about two patients that had survived, a similar operation - But not about others that had died. The BBC's Deborah Cohen asks if Shauna died After Two Weeks , was a victim of the rush to the stem cell Technology ?

Shauna Davison was born with a lung, a cleft palate and a heart defect. But despite spending her life in and out of The Hospital , she remained a happy child.

"her disease she never got down and you had always said a smile on her face," Shauna's mother, Karen Davison. "Everyone was so nice to her. You looked over your problems. "

When she was 12 weeks old, the doctors find problems with your trachea or windpipe. It was very tight and when it's disabled, you couldn't Breathe . It has a life of 48 Hours .

Karen Davison: "she was a naughty child, But loved by all" a surgeon in Leeds, came to The Rescue . David Crabbe warned that it might not work, But he managed to get back to Shauna to build up the air tube from the ribs.

Shauna had to stay in hospital for six months and had to put the ring-shaped stent to keep her windpipe open.

Mr Crabbe was really caring, Karen Davison says. "The Hospital was excellent. "

over The Years , Shauna's stent Dilatation is needed, as they getting bigger and bigger. She had to Breathe , a tracheostomy - an opening in The Front of the Neck , to help her.

"There were times we did not think you would make it, because they kept collapsing," says Karen Davison says.

you can Find out moreAt Home in Middlesbrough, she has learned to change, Shauna's tracheostomy tube, use a fan, do you have physiotherapy to help her clear her airway, suctioning her airway, perform CPR, and give her antibiotics.

"I did everything for you," she says. "Shauna is a wonderful deal. But you don't know it differently. "

An avid Middlesbrough Football Club fan, Shauna loved to wear a football kit. They went to a mainstream school, the mix with the support of a caregiver, where she could be with other children.

"she was a naughty child, But loved by all," says the mother. "It brightens every day. "

Shauna had many operations, But they would always come through. Sometimes, she didn't want to go near a hospital, for the age, Karen says.

A time came, however, when David Crabbe no longer told her His technique for The Treatment of Shauna was sufficient. Your respiratory tract is too small and you see have to to look for other options.

"Mr. Crabbe showed me pictures of a normal airline and your Airways. It was tiny," Karen Davison says.

Shauna to go steps to the Great Ormond Street Hospital (GOSH) in London, which is modified for the tests and their stent. In 2011, the doctors there told her the airline would not last much longer.

15, Shauna suffered a respiratory arrest - a serious incident in which she was not able to Breathe and The Family was told about a pioneering Operation by Professor Martin Elliott, a cardiac-thoracic surgeon and former medical Director of Great Ormond Street Hospital.

"you said it would, some of the research in tracheal Transplantation, and there are two other cases, where it would have done, But you could not say you are talking with me because of the secrecy," says Karen Davison One of them was a 10-year-old boy, she adds.

"It would be the only chance you would have. "

Shauna's transplant was not a conventional one.

you will receive a donor trachea, But it would be laced with their own stem cells, so that it is almost like your own. You would not need drugs to discard in order to stop your body. It was at the top of the new stem cell Technology and is still very experimental.

Doctors can treatments experimental, if someone is terminally ill and there is no alternative treatment. It's called "compassionate use".

Karen says, she was told that Shauna would not need a tracheostomy, or a ventilator, and they would lead a normal life. But she was told about the risks, she adds - Shauna could still have the transplant reject, and General anesthesia is never without risk.

Martin Elliott previously worked closely with the internationally renowned Martin Birchall, professor of otorhinolaryngology at the University College London (UCL), to implant a stem cell-laced donor trachea in Another Child . They would be Together Again in Shauna's case.

Shauna was treated in Great Ormond Street in the time of a BBC documentary about The Hospital in the year 2012. It was on the basis of Different specialists and asked what were her hopes for The Future . Shauna said respiratory consultant Dr. Martin Wallis, she wanted to go to be able to swim.

It was not an easy decision for the operation. Martin Wallis's words, it was not a situation where it would lose nothing more.

"you have a lot to lose. And that will be a difficult decision," he said. "She has a reasonable quality of life, she has her good friend, she clearly has a sense of Humor and is self-enjoy - it makes it harder. "

"I wanted to say that you have done it while she was waiting, rather than until she was sick, and it could not happen," Karen Davison.

But because it was an experimental procedure, your medical Team discussed it with the Great Ormond Street Hospital ethics committee.

"I don't think you are going to die, when we the procedure. We are not to try the method so. Or at least extend their lives and quality of life for as long as possible," The Surgeon , Martin Elliott, told The Committee in front of the camera.

"you couldn't give me a time when you would die, But She Said she is going to die at some point. Because their respiratory system would simply give up. So it was this procedure, and you said you were willing to do that," Karen Davison says. "Like all other parents, if you thought this would help your child's life, I agreed. "

So in February 2012, Shauna received a transplant of a donor trachea re-populated with their own stem cells.

Shauna's transplant seemed to go well, it was filmed by the BBC Initially. "For The First few days she was reminded of wonderful," her mother. "I couldn't believe how well you are recovering After it. "

Two Weeks After your Surgery , Shauna has been moved from Great Ormond Street with the ambulance to a hospital in Leeds. But during the transfer, Shauna a lot, began to cough and was in need of suction to clear her throat.

"We thought that was strange, But thought it could have been says because of the trip," Karen Davison. "I was just thinking" a couple of weeks, and we will be Home . '"

Shauna took But the next morning, a turn for the worse.

"her head was in," says Karen . She remembers Shauna say, "Help me, help me. "

"It was the worst day in My Life , because I could not help her. "

Shauna's new trachea was collapsing.

"you said you'd gave up, struggled to Breathe that much, and her heart," Karen Davison says.

"she was a wonderful child. I miss you so much. "

If The First transplant with a donated trachea coated with the patient's own stem cells was carried out in 2008, made the global headlines.

It was assumed that the Stripping of The Donor of the cells from The Surface of the trachea and seeding it with the patient's own stem cells are created, the new organ would be, as the patient's own tissue. No anti-rejection drugs, the "tissue engineered" windpipe would be required.

The Surgery was performed by the Italian surgeon Paolo Macchiarini , with The Help of Martin Birchall, a surgeon at the University of Bristol. The recipient of the 30-year-old Claudia Castillo had tuberculosis, which results in a part of your trachea, the Lungs , the bronchi.

her case was written up in The Lancet. Five months After she had her operation, it was reported that in Perfect Health .

Martin Birchall, who had helped to prepare The Donor trachea, said at the time, it would be ". Surgeons can now start to see and understand the potential for adult stem cells and tissue engineering to radically improve their ability to treat patients with serious diseases. "

Many around The World agree. It was a "", "unadulterated good news" and "".

"He was regarded as a revolutionary, as a highly innovative... open the door for new and exciting tech with a marriage between stem cells and artificial scaffolds, which could bring in this completely new field of regenerative medicine," recalls Prof John Rasko from the University of Sydney Faculty of Health Sciences.

you have "the touch of Nobel Prize about you," he says.

in fact, soon the University, which hands out the Nobel Prize for medicine, Stockholm's renowned Karolinska Institute , a post offered, Macchiarini. Birchall, for His part, moved to University College London (UCL), where Macchiarini is also an honorary Professor. to be

began, But soon questions will be asked about the stem cell-laced tracheas.

middlesbrough, great ormond street hospital, stem cells, long reads, medical ethics, university college london, transplants

Source of news: bbc.com